Receptor-mediated endocytosis of plasminogen activators and activator/inhibitor complexes.

@article{Andreasen1994ReceptormediatedEO,
  title={Receptor-mediated endocytosis of plasminogen activators and activator/inhibitor complexes.},
  author={Peter Andr{\'e} Andreasen and Lars Sottrup-Jensen and Lars Kj\oller and Anders Nykjaer and Soren K. Moestrup and Claus Munck Petersen and J\orgen Gliemann},
  journal={FEBS letters},
  year={1994},
  volume={338 3},
  pages={239-45}
}
Recent findings have elucidated the mechanism for clearance from the extracellular space of the two types of plasminogen activators, urokinase-type plasminogen activator (u-PA) and tissue-type plasminogen activator (t-PA), and their type-1 inhibitor (PAI-1). Activator/PAI-1 complexes and uncomplexed t-PA bind to the multi-ligand receptors alpha 2… CONTINUE READING