Receptor-mediated endocytosis of immunoglobulin light chains by renal proximal tubule cells.

@article{Batuman1997ReceptormediatedEO,
  title={Receptor-mediated endocytosis of immunoglobulin light chains by renal proximal tubule cells.},
  author={Vecihi Batuman and Shuwen Guan},
  journal={The American journal of physiology},
  year={1997},
  volume={272 4 Pt 2},
  pages={F521-30}
}
We examined the binding, endocytosis, and degradation of immunoglobulin light chains by primary cultures from rat renal kidneys and immortalized human proximal tubule cells. Both the association and dissociation of light chain were rapid and plateaued within 30 min at 4 degrees C. Up to 10(-3) M bovine serum albumin did not inhibit light chain binding to cells. Internalization studies with 125I-labeled kappa- and lambda-light chains by cells using the acid wash technique showed that up to 80… CONTINUE READING

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