Receptor-mediated endocytosis of Neisseria gonorrhoeae into primary human urethral epithelial cells: the role of the asialoglycoprotein receptor.

@article{Harvey2001ReceptormediatedEO,
  title={Receptor-mediated endocytosis of Neisseria gonorrhoeae into primary human urethral epithelial cells: the role of the asialoglycoprotein receptor.},
  author={Hillary A. Harvey and Michael P Jennings and Colleen A. Campbell and Rc Williams and Michael A. Apicella},
  journal={Molecular microbiology},
  year={2001},
  volume={42 3},
  pages={
          659-72
        }
}
Urethral epithelial cells are invaded by Neisseria gonorrhoeae during gonococcal infection in men. To understand further the mechanisms of gonococcal entry into host cells, we used the primary human urethral epithelial cells (PHUECs) tissue culture system recently developed by our laboratory. These studies showed that human asialoglycoprotein receptor (ASGP-R) and the terminal lactosamine of lacto-N-neotetraose-expressing gonococcal lipooligosaccharide (LOS) play an important role in invasion… CONTINUE READING

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