Receptor-mediated activation of murine peritoneal macrophages by antithrombin III acts as a costimulatory signal for nitric oxide synthesis.

@article{Kwak1998ReceptormediatedAO,
  title={Receptor-mediated activation of murine peritoneal macrophages by antithrombin III acts as a costimulatory signal for nitric oxide synthesis.},
  author={J Y Kwak and Seung Yong Park and Myung Kwan Han and Hyun Soon Lee and Myung Hyun Sohn and Uh Hee Kim and John R. McGregor and Wolfram E Samlowski and Chang Yeol Yim},
  journal={Cellular immunology},
  year={1998},
  volume={188 1},
  pages={33-40}
}
We evaluated the effect of antithrombin III (ATIII), a serine protease inhibitor (SERPIN), on induction of nitric oxide (NO) synthesis in murine peritoneal macrophages. Incubation of macrophages with ATIII plus interferon-gamma (IFN-gamma) but not ATIII alone induced nitrite accumulation (a metabolite of NO) in a dose-dependent manner. Expression of the… CONTINUE READING