Receptor-mediated activation of a proinsulin-transferrin fusion protein in hepatoma cells.


A proinsulin-transferrin (ProINS-Tf) recombinant fusion protein was designed and characterized for the sustained release of an active form of insulin (INS) by hepatoma cells. During incubation with H4IIE hepatoma cells, a gradual decline of ProINS-Tf concentration, with a concomitant generation of the immuno-reactive insulin-transferrin (irINS-Tf), was… (More)
DOI: 10.1016/j.jconrel.2011.06.029


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