Receptor-mediated activation of G proteins is increased in postmortem brains of bipolar affective disorder subjects.

@article{Friedman1996ReceptormediatedAO,
  title={Receptor-mediated activation of G proteins is increased in postmortem brains of bipolar affective disorder subjects.},
  author={Eitan Friedman and Huaixing Wang},
  journal={Journal of neurochemistry},
  year={1996},
  volume={67 3},
  pages={1145-52}
}
Guanine nucleotide binding proteins (G proteins) have been implicated in the pathophysiology of bipolar affective disorder. In the present investigation receptor-mediated G protein activation and changes in G protein trimeric state were examined in frontal cortical membranes obtained from postmortem brains of bipolar affective disorder subjects and from age-, sex-, and postmortem interval-matched controls. Stimulation of cortical membranes with serotonin, isoproterenol, or carbachol increased… CONTINUE READING

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