Receptor mediated action without receptor occupancy.

  title={Receptor mediated action without receptor occupancy.},
  author={William H. Fletcher and Jamie Greenan},
  volume={116 4},
The relationship between occupancy of a specific cell surface receptor and actions initiated in the same cell by that event was tested on ovarian granulosa cells exposed to hCG. Hormone bound to its receptor was identified by immunocytochemistry or by autoradiography and the dissociation of cAMP-dependent protein kinase was followed by direct cytochemistry. Only 25-30% of the granulosa cells bound hCG and in each instance this resulted in protein kinase dissociation. Cells that did not bind hCG… CONTINUE READING

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