Receptor mechanisms mediating cyanide generation in PC12 cells and rat brain

@article{Gunasekar2004ReceptorMM,
  title={Receptor mechanisms mediating cyanide generation in PC12 cells and rat brain},
  author={Palur G. Gunasekar and Krishnan Prabhakaran and Li Feng Li and L W Zhang and Joseph L. Borowitz},
  journal={Neuroscience Research},
  year={2004},
  volume={49},
  pages={13-18}
}
Cyanide is generated in neurons and this report examines the two different receptors which mediate cyanide formation in neuronal tissue. An opiate receptor blocked by naloxone increases cyanide production both in rat brain and in rat pheochromocytoma (PC12) cells. A muscarinic receptor in PC12 cells releases cyanide and the effect is blocked by atropine. In rat brain, in vivo, a muscarinic agonist inhibits cyanide generation, possibly by acting on receptor subtypes different from those in PC12… Expand
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