Receptor-ligand binding assays: technologies and applications.

  title={Receptor-ligand binding assays: technologies and applications.},
  author={Lutea A A de Jong and Donald R. A. Uges and Jan Piet Franke and Rainer Bischoff},
  journal={Journal of chromatography. B, Analytical technologies in the biomedical and life sciences},
  volume={829 1-2},
Receptor-ligand interactions play a crucial role in biological systems and their measurement forms an important part of modern pharmaceutical development. Numerous assay formats are available that can be used to screen and quantify receptor ligands. In this review, we give an overview over both radioactive and non-radioactive assay technologies with emphasis on the latter. While radioreceptor assays are fast, easy to use and reproducible, their major disadvantage is that they are hazardous to… CONTINUE READING