Receptor interaction profiles of novel psychoactive tryptamines compared with classic hallucinogens

  title={Receptor interaction profiles of novel psychoactive tryptamines compared with classic hallucinogens},
  author={A. Rickli and Olivier D. Moning and M. Hoener and M. Liechti},
  journal={European Neuropsychopharmacology},
  • A. Rickli, Olivier D. Moning, +1 author M. Liechti
  • Published 2016
  • Chemistry, Medicine
  • European Neuropsychopharmacology
  • The present study investigated interactions between the novel psychoactive tryptamines DiPT, 4-OH-DiPT, 4-OH-MET, 5-MeO-AMT, and 5-MeO-MiPT at monoamine receptors and transporters compared with the classic hallucinogens lysergic acid diethylamide (LSD), psilocin, N,N-dimethyltryptamine (DMT), and mescaline. We investigated binding affinities at human monoamine receptors and determined functional serotonin (5-hydroxytryptamine [5-HT]) 5-HT2A and 5-HT2B receptor activation. Binding at and the… CONTINUE READING
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