Receptor interacting protein kinase-mediated necrosis contributes to cone and rod photoreceptor degeneration in the retina lacking interphotoreceptor retinoid-binding protein.

@article{Sato2013ReceptorIP,
  title={Receptor interacting protein kinase-mediated necrosis contributes to cone and rod photoreceptor degeneration in the retina lacking interphotoreceptor retinoid-binding protein.},
  author={Kota Sato and Songhua Li and William Charles Gordon and Jibao He and Gregory Ing Liou and James M. Hill and Gabriel H. Travis and Nicolas G Bazan and Minghao Jin},
  journal={The Journal of neuroscience : the official journal of the Society for Neuroscience},
  year={2013},
  volume={33 44},
  pages={
          17458-68
        }
}
Interphotoreceptor retinoid-binding protein (IRBP) secreted by photoreceptors plays a pivotal role in photoreceptor survival with an unknown mechanism. A mutation in the human IRBP has been linked to retinitis pigmentosa, a progressive retinal degenerative disease. Mice lacking IRBP display severe early and progressive photoreceptor degeneration. However, the signaling pathway(s) leading to photoreceptor death in IRBP-deficient mice remains poorly understood. Here, we show that amounts of tumor… CONTINUE READING

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