Receptor-independent protein kinase C alpha (PKCalpha) signaling by calpain-generated free catalytic domains induces HDAC5 nuclear export and regulates cardiac transcription.

@article{Zhang2011ReceptorindependentPK,
  title={Receptor-independent protein kinase C alpha (PKCalpha) signaling by calpain-generated free catalytic domains induces HDAC5 nuclear export and regulates cardiac transcription.},
  author={Yan Hong Zhang and Scot J Matkovich and Xiujun Duan and Abhinav Diwan and Min-Young Kang and Gerald W. Dorn},
  journal={The Journal of biological chemistry},
  year={2011},
  volume={286 30},
  pages={26943-51}
}
Receptor-mediated activation of protein kinase (PK) C is a central pathway regulating cell growth, homeostasis, and programmed death. Recently, we showed that calpain-mediated proteolytic processing of PKCα in ischemic myocardium activates PKC signaling in a receptor-independent manner by releasing a persistent and constitutively active free catalytic fragment, PKCα-CT. This unregulated kinase provokes cardiomyopathy, but the mechanisms remain unclear. Here, we demonstrate that PKCα-CT is a… CONTINUE READING

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