Receptor-independent intracellular radical scavenging activity of an angiotensin II receptor blocker.

@article{Shao2007ReceptorindependentIR,
  title={Receptor-independent intracellular radical scavenging activity of an angiotensin II receptor blocker.},
  author={Jing Shao and Masaomi Nangaku and Reiko Inagi and Hideki Kato and Toshio Miyata and Taiji Matsusaka and Eisei Noiri and Toshiro Fujita},
  journal={Journal of hypertension},
  year={2007},
  volume={25 8},
  pages={1643-9}
}
OBJECTIVES Angiotensin II plays a crucial role in the induction of oxidative stress and the pathogenesis of cardiovascular and renal diseases, and the beneficial mechanisms of angiotensin II receptor 1 blockers (ARBs) are multifactorial. We investigated the receptor-independent protective role of an ARB using primary-cultured mesangial cells from angiotensin II receptor 1 knockout or wild-type mice and a highly lipophilic ARB, telmisartan. METHODS AND RESULTS Intracellular reactive oxygen… CONTINUE READING

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