Receptor heteromerization in adenosine A2A receptor signaling

@article{Fuxe2003ReceptorHI,
  title={Receptor heteromerization in adenosine A2A receptor signaling},
  author={K. Fuxe and L. Agnati and K. Jacobsen and J. Hillion and M. Canals and M. Torvinen and B. Tinner-Staines and W. Staines and D. Rosin and A. Terasmaa and P. Popoli and G. Leo and V. Vergoni and C. Lluis and F. Ciruela and R. Franco and S. Ferr{\'e}},
  journal={Neurology},
  year={2003},
  volume={61},
  pages={S19 - S23}
}
  • K. Fuxe, L. Agnati, +14 authors S. Ferré
  • Published 2003
  • Biology, Chemistry, Medicine
  • Neurology
    • Recently evidence has been presented that adenosine A2A and dopamine D2 receptors form functional heteromeric receptor complexes as demonstrated in human neuroblastoma cells and mouse fibroblast Ltk− cells. These A2A/D2 heteromeric receptor complexes undergo coaggregation, cointernalization, and codesensitization on D2 or A2A receptor agonist treatments and especially after combined agonist treatment. It is hypothesized that the A2A/D2 receptor heteromer represents the molecular basis for the… CONTINUE READING
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