Receptor for motilin identified in the human gastrointestinal system.

  title={Receptor for motilin identified in the human gastrointestinal system.},
  author={Scott D. Feighner and Carina P. Tan and Karen Kulju McKee and Oksana C. Palyha and Donna L. Hreniuk and S S Pong and Christopher P. Austin and Dolores Figueroa and Donna MacNeil and Margaret A. Cascieri and Ravi P Nargund and Raman Bakshi and Mark Abramovitz and Rino Stocco and Stacia Kargman and G O'neill and Lex H. T. van der Ploeg and Jamie Evans and Arthur A. Patchett and R. G. Smith and Andrew D. Howard},
  volume={284 5423},
Motilin is a 22-amino acid peptide hormone expressed throughout the gastrointestinal (GI) tract of humans and other species. It affects gastric motility by stimulating interdigestive antrum and duodenal contractions. A heterotrimeric guanosine triphosphate-binding protein (G protein)-coupled receptor for motilin was isolated from human stomach, and its amino acid sequence was found to be 52 percent identical to the human receptor for growth hormone secretagogues. The macrolide antibiotic… CONTINUE READING