Receptor for glucocorticoids in RPMI 3460 melanoma cells.

  title={Receptor for glucocorticoids in RPMI 3460 melanoma cells.},
  author={E. F. Hawkins and Debra S Horn and Francis S. Markland},
  journal={Cancer research},
  volume={40 7},
We are investigating the role of steroid hormones in the biological behavior of malignant melanoma. We have recently shown that the growth of RPMI 3460 Syrian hamster melanoma cells in monolayer culture is retarded by the synthetic glucocorticoid dexamethasone. This paper reports the identification of a macromolecule with properties of a glucocorticoid receptor in cytosis prepared from these cells. Sucrose density gradient analyses on six separate cell batches consistently demonstrated… CONTINUE READING

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