Receptor for complement peptide C3a: a therapeutic target for neonatal hypoxic-ischemic brain injury.

@article{Jrlestedt2013ReceptorFC,
  title={Receptor for complement peptide C3a: a therapeutic target for neonatal hypoxic-ischemic brain injury.},
  author={Katarina J{\"a}rlestedt and Catherine I. Rousset and Anders St{\aa}hlberg and Hana {\vS}ourkov{\'a} and Alison L Atkins and Claire Thornton and Scott Robert Barnum and Rick A Wetsel and Mike Dragunow and Milos Pekny and Carina Mallard and Henrik H Hagberg and Marcela Pekna},
  journal={FASEB journal : official publication of the Federation of American Societies for Experimental Biology},
  year={2013},
  volume={27 9},
  pages={3797-804}
}
Complement is an essential component of inflammation that plays a role in ischemic brain injury. Recent reports demonstrate novel functions of complement in normal and diseased CNS, such as regulation of neurogenesis and synapse elimination. Here, we examined the role of complement-derived peptide C3a in unilateral hypoxia-ischemia (HI), a model of neonatal HI encephalopathy. HI injury was induced at postnatal day 9 (P9), and loss of hippocampal tissue was determined on P31. We compared WT mice… CONTINUE READING
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