Receptor for advanced glycation end products activation injures primary sensory neurons via oxidative stress.

@article{Vincent2007ReceptorFA,
  title={Receptor for advanced glycation end products activation injures primary sensory neurons via oxidative stress.},
  author={Andrea M. Vincent and Lorena Perrone and Kelli A. Sullivan and Carey Backus and Ann Marie Sastry and Christian M Lastoskie and Eva L. Feldman},
  journal={Endocrinology},
  year={2007},
  volume={148 2},
  pages={548-58}
}
The receptor for advanced glycation end products (RAGE) may promote diabetic vascular and renal disease through the activation of intracellular signaling pathways that promote oxidative stress. Oxidative stress is a mediator of hyperglycemia-induced cell injury and a unifying theme for all mechanisms of diabetic complications, but there are few studies on the expression and potential contribution of RAGE in diabetic neuropathy. The current study demonstrates that dorsal root ganglia neurons… CONTINUE READING

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