Receptor for advanced glycation end product (RAGE) upregulation in human gingival fibroblasts incubated with nornicotine.

@article{Katz2005ReceptorFA,
  title={Receptor for advanced glycation end product (RAGE) upregulation in human gingival fibroblasts incubated with nornicotine.},
  author={Joseph Katz and Robert M Caudle and Indraneel B Bhattacharyya and Carol M. Stewart and D. M. Cohen},
  journal={Journal of periodontology},
  year={2005},
  volume={76 7},
  pages={1171-4}
}
BACKGROUND Clinical and epidemiological data strongly support a link between smoking and periodontal disease. The mechanism by which smoking contributes to the destruction of periodontal tissue is not clear and cannot be attributed solely to the vasoconstrictive effects of nicotine. Our hypothesis is that nornicotine, a metabolite of nicotine, upregulates the expression of the receptor for the advanced glycation end products (RAGE) in the gingiva of smokers and triggers the proinflammatory… CONTINUE READING
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