Receptor for Advanced Glycation End Products and Its Involvement in Inflammatory Diseases

  title={Receptor for Advanced Glycation End Products and Its Involvement in Inflammatory Diseases},
  author={Yaw Kuang Chuah and Rusliza Basir and Herni Talib and Tung Hing Tie and Norshariza Nordin},
  booktitle={International journal of inflammation},
The receptor for advanced glycation end products (RAGE) is a transmembrane receptor of the immunoglobulin superfamily, capable of binding a broad repertoire of ligands. RAGE-ligands interaction induces a series of signal transduction cascades and lead to the activation of transcription factor NF-κB as well as increased expression of cytokines, chemokines, and adhesion molecules. These effects endow RAGE with the role in the signal transduction from pathogen substrates to cell activation during… CONTINUE READING


Publications citing this paper.
Showing 1-10 of 57 extracted citations

Role of RAGE in Alzheimer’s Disease

Cellular and Molecular Neurobiology • 2015
View 4 Excerpts
Highly Influenced

Characterization of immune cells in psoriatic adipose tissue

Journal of Translational Medicine • 2014
View 7 Excerpts
Highly Influenced


Publications referenced by this paper.
Showing 1-10 of 109 references


E. C. Lutterloh, S. M. Opal
D. Pittman et al., “Inhibition of the RAGE products increases survival in experimental models of severe sepsis and systemic infection,”Critical Care, vol. 11, no. 6, article R122 • 2007
View 6 Excerpts
Highly Influenced

Atherosclerosis--an inflammatory disease.

The New England journal of medicine • 1999
View 3 Excerpts
Highly Influenced

A role for the receptor for advanced glycation end products in idiopathic pulmonary fibrosis

L. E. Hanford, N. Kaminski
TheAmerican Journal of Pathology • 2012


M. B. Sukkar, L. G. Wood
Tooze et al., “Soluble RAGE is deficient in neutrophilic asthma and COPD,” European Respiratory Journal, vol. 39, no. 3, pp. 721–729 • 2012


Y. Zhou, Y. Q. Jiang
X. Wang et al., “HMGB1 and RAGE levels in induced sputum correlate with asthma severity and neutrophil percentage,” Human Immunology, vol. 73, no. 11, pp. 1171–1174 • 2012


V. Srikanth, A. Maczurek
Phan et al., “Advanced glycation endproducts and their receptor RAGE in Alzheimer’s disease,” Neurobiology of Aging, vol. 32, no. 5, pp. 763–777 • 2011

Similar Papers

Loading similar papers…