Receptor for Advanced Glycation End Products and Its Involvement in Inflammatory Diseases

@inproceedings{Chuah2013ReceptorFA,
  title={Receptor for Advanced Glycation End Products and Its Involvement in Inflammatory Diseases},
  author={Yaw Kuang Chuah and Rusliza Basir and Herni Talib and Tung Hing Tie and Norshariza Nordin},
  booktitle={International journal of inflammation},
  year={2013}
}
The receptor for advanced glycation end products (RAGE) is a transmembrane receptor of the immunoglobulin superfamily, capable of binding a broad repertoire of ligands. RAGE-ligands interaction induces a series of signal transduction cascades and lead to the activation of transcription factor NF-κB as well as increased expression of cytokines, chemokines, and adhesion molecules. These effects endow RAGE with the role in the signal transduction from pathogen substrates to cell activation during… CONTINUE READING

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