Receptor for Advanced Glycation End Products (RAGE) Deficiency Attenuates the Development of Atherosclerosis in Diabetes

@article{SoroPaavonen2008ReceptorFA,
  title={Receptor for Advanced Glycation End Products (RAGE) Deficiency Attenuates the Development of Atherosclerosis in Diabetes},
  author={Aino Soro-Paavonen and Anna M. D. Watson and Jiaze Li and Karri Paavonen and Audrey Koitka and Anna C. Calkin and David Barit and Melinda T. Coughlan and Brian G. Drew and Graeme Iain Lancaster and Merlin C Thomas and Josephine M Forbes and Peter P Nawroth and Angelika Bierhaus and Mark Cooper and Karin Jandeleit-Dahm},
  journal={Diabetes},
  year={2008},
  volume={57},
  pages={2461 - 2469}
}
OBJECTIVE Activation of the receptor for advanced glycation end products (RAGE) in diabetic vasculature is considered to be a key mediator of atherogenesis. This study examines the effects of deletion of RAGE on the development of atherosclerosis in the diabetic apoE(-/-) model of accelerated atherosclerosis. RESEARCH DESIGN AND METHODS ApoE(-/-) and RAGE(-/-)/apoE(-/-) double knockout mice were rendered diabetic with streptozotocin and followed for 20 weeks, at which time plaque accumulation… CONTINUE READING

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