Receptor for Advanced Glycation End Products (RAGE) on iNKT Cells Mediates Lung Ischemia-Reperfusion Injury

@article{Sharma2013ReceptorFA,
  title={Receptor for Advanced Glycation End Products (RAGE) on iNKT Cells Mediates Lung Ischemia-Reperfusion Injury},
  author={Ashish K Sharma and Damien J LaPar and Matthew L. Stone and Yong Zhao and Irving L. Kron and Victor E Laubach},
  journal={American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons},
  year={2013},
  volume={13 9},
  pages={2255-67}
}
Activation of invariant natural killer T (iNKT) cells and signaling through receptor for advanced glycation end products (RAGE) are known to independently mediate lung ischemia-reperfusion (IR) injury. This study tests the hypothesis that activation of RAGE specifically on iNKT cells via alveolar macrophage-produced high mobility group box 1 (HMGB1) is critical for the initiation of lung IR injury. A murine in vivo hilar clamp model was utilized, which demonstrated that RAGE(-/-) mice were… CONTINUE READING

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Involvement of interleukin-17 during lymphocytic bronchiolitis in lung transplant patients.

The Journal of heart and lung transplantation : the official publication of the International Society for Heart Transplantation • 2013

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