Receptor for AGE (RAGE) and its ligands—cast into leading roles in diabetes and the inflammatory response

@article{Yan2009ReceptorFA,
  title={Receptor for AGE (RAGE) and its ligands—cast into leading roles in diabetes and the inflammatory response},
  author={Shi Fang Yan and Ravichandran Ramasamy and Ann Marie Schmidt},
  journal={Journal of Molecular Medicine},
  year={2009},
  volume={87},
  pages={235-247}
}
The actors in the pathogenesis of diabetes and its complications are many and multifaceted. The effects of elevated levels of glucose are myriad; among these is the generation of advanced glycation end products (AGEs), the products of nonenzymatic glycoxidation of proteins and lipids. The finding that AGEs stimulate signal transduction cascades through the multiligand receptor RAGE unveiled novel insights into diabetes and its complications. Inextricably woven into AGE–RAGE interactions in… CONTINUE READING

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