Receptor extracellular domains may contain trafficking information. Studies of the 300-kDa mannose 6-phosphate receptor.

@article{Dintzis1994ReceptorED,
  title={Receptor extracellular domains may contain trafficking information. Studies of the 300-kDa mannose 6-phosphate receptor.},
  author={Suzanne M. Dintzis and Victor E. Velculescu and Suzanne R Pfeffer},
  journal={The Journal of biological chemistry},
  year={1994},
  volume={269 16},
  pages={12159-66}
}
The 300-kDa mannose 6-phosphate receptor cycles between the trans Golgi network and late endosomes, and between the plasma membrane and early endosomes, to deliver lysosomal enzymes to prelysosomes. Mannose 6-phosphate receptor trafficking requires structural determinants present in the cytoplasmic domain. However, when this domain was joined with the extracellular and transmembrane domains of the epidermal growth factor receptor, it was not sufficient to direct this chimera to late endosomes… CONTINUE READING

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