Receptor endocytosis via ubiquitin-dependent and -independent pathways.

  title={Receptor endocytosis via ubiquitin-dependent and -independent pathways.},
  author={Daniela Hoeller and Ivan Dikic},
  journal={Biochemical pharmacology},
  volume={67 6},
The controlled termination of signaling pathways after their ligand-induced activation is an important mechanism to ensure appropriate signal intensity and the consequent cellular response. Most cell surface receptors are downregulated by receptor endocytosis and subsequent lysosomal degradation, processes accompanied by attachment of ubiquitin (Ub) molecules to activated receptors and associated proteins. A significant body of evidence supports the view that mono-Ub functions as an important… CONTINUE READING

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