Receptor editing in lymphocyte development and central tolerance

@article{Nemazee2006ReceptorEI,
  title={Receptor editing in lymphocyte development and central tolerance},
  author={David Nemazee},
  journal={Nature Reviews Immunology},
  year={2006},
  volume={6},
  pages={728-740}
}
  • D. Nemazee
  • Published 1 October 2006
  • Biology, Medicine
  • Nature Reviews Immunology
The specificities of lymphocytes for antigen are generated by a quasi-random process of gene rearrangement that often results in non-functional or autoreactive antigen receptors. Regulation of lymphocyte specificities involves not only the elimination of cells that display 'unsuitable' receptors for antigen but also the active genetic correction of these receptors by secondary recombination of the DNA. As I discuss here, an important mechanism for the genetic correction of antigen receptors is… 
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