Receptor editing in a transgenic mouse model: site, efficiency, and role in B cell tolerance and antibody diversification.

@article{Pelanda1997ReceptorEI,
  title={Receptor editing in a transgenic mouse model: site, efficiency, and role in B cell tolerance and antibody diversification.},
  author={Roberta Pelanda and Stephan Schwers and Eiichiro Sonoda and Raul M Torres and David Nemazee and K. Rajewsky},
  journal={Immunity},
  year={1997},
  volume={7 6},
  pages={765-75}
}
Mice carrying transgenic rearranged V region genes in their IgH and Igkappa loci to encode an autoreactive specificity direct the emerging autoreactive progenitors into a pre-B cell compartment, in which their receptors are edited by secondary Vkappa-Jkappa rearrangements and RS recombination. Editing is an efficient process, because the mutant mice generate normal numbers of B cells. In a similar nonautoreactive transgenic strain, neither a pre-B cell compartment nor receptor editing was seen… CONTINUE READING

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