Receptor-dependent and receptor-independent endocannabinoid signaling: a therapeutic target for regulation of cancer growth.

@article{Dross2013ReceptordependentAR,
  title={Receptor-dependent and receptor-independent endocannabinoid signaling: a therapeutic target for regulation of cancer growth.},
  author={Rukiyah Van Dross and Eman Soliman Soliman and Shalini Jha and Travious Johnson and Somnath Mukhopadhyay},
  journal={Life sciences},
  year={2013},
  volume={92 8-9},
  pages={463-6}
}
The endocannabinoid system comprises the G-protein coupled CB1 cannabinoid receptor (CB1R) and CB2 cannabinoid receptor (CB2R), their endogenous ligands (endocannabinoids), and the enzymes responsible for their synthesis and catabolism. Recent works have revealed several important interactions between the endocannabinoid system and cancer. Moreover, it is now well established that synthetic small molecule cannabinoid receptor agonist acting on either CB1R or CB2R or both exerts anti-cancer… CONTINUE READING