Receptor density and recycling affect the rate of agonist-induced desensitization of mu-opioid receptor.

@article{Law2000ReceptorDA,
  title={Receptor density and recycling affect the rate of agonist-induced desensitization of mu-opioid receptor.},
  author={Ping-Yee Law and Linda J. Erickson and Rachid El-Kouhen and Lee H. Dicker and Jan Ketil Solberg and Wei Wang and Edmund J Miller and A. A. Burd and Horace H. Loh},
  journal={Molecular pharmacology},
  year={2000},
  volume={58 2},
  pages={
          388-98
        }
}
Previously, we reported that the time course for the rapid phosphorylation rate of mu-opioid receptor expressed in human embryonic kidney (HEK)293 cells did not correlate with the slow receptor desensitization rate induced by [D-Ala(2),N-MePhe(4), Gly-ol(5)]-enkephalin (DAMGO). However, others have suggested that receptor phosphorylation is the trigger for mu-opioid receptor desensitization. In this study, we demonstrated the relatively slow rate of receptor desensitization could be attributed… CONTINUE READING

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