Receptor binding profile suggests multiple mechanisms of action are responsible for ibogaine's putative anti-addictive activity

Abstract

The indole alkaloid ibogaine (NIH 10567, Endabuse) is currently being examined for its potential utility in the treatment of cocaine and opioid addiction. However, a clearly defined molecular mechanism of action for ibogaine's putative anti-addictive properties has not been delineated. Radioligand binding assays targeting over 50 distinct neurotransmitter… (More)
DOI: 10.1007/BF02245936

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