• Chemistry, Medicine
  • Published in
    European Journal of Clinical…
    1985
  • DOI:10.1007/BF00547412

Receptor binding of propranolol is the missing link between plasma concentration kinetics and the effect-time course in man

@article{Wellstein1985ReceptorBO,
  title={Receptor binding of propranolol is the missing link between plasma concentration kinetics and the effect-time course in man},
  author={Anton Wellstein and Dieter Palm and Heinz Friedrich Pitschner and Gustav Georg Belz},
  journal={European Journal of Clinical Pharmacology},
  year={1985},
  volume={29},
  pages={131-147}
}
SummaryIn a double-blind, placebo-controlled study in 6 healthy volunteers, the correlation between beta-adrenoceptor binding, the time course of the effect and plasma concentration kinetics was investigated from 0 to 48 h after a single oral dose of propranolol 240 mg. First, the in vitro beta-adrenoceptor interaction of propranolol was investigated. Propranolol inhibited beta-adrenoceptor binding to rat parotid (beta1) and reticulocyte (beta2) membranes in the presence of pooled human plasma… CONTINUE READING

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  • 1984