Receptor assay guided structure-activity studies of helicokinin insect neuropeptides and peptidomimetic analogues.

@article{Scherkenbeck2009ReceptorAG,
  title={Receptor assay guided structure-activity studies of helicokinin insect neuropeptides and peptidomimetic analogues.},
  author={Juergen Scherkenbeck and Horst-Peter Antonicek and Kathrin Vogelsang and Tino Zdobinsky and Karin Br{\"u}cher and Denise Rehl{\"a}nder and He-ru Chen},
  journal={Journal of peptide science : an official publication of the European Peptide Society},
  year={2009},
  volume={15 11},
  pages={
          783-9
        }
}
Neuropeptides control numerous physiological processes in insects. The regulation of water balance is a crucial aspect of homeostasis in terrestrial insects and has been shown to be under endocrine control, primarily by corticotrophin releasing factor (CRF)-related peptides and kinins. For helicokinin I, a diuretic neuropeptide from the economically important insect pest Heliothis virescens, detailed structure-activity relationships have been established based on truncated structures, diverse… CONTINUE READING

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