Receptor and mechanism that mediate endothelin- and big endothelin-1-induced phosphoinositide hydrolysis in the rat spinal cord.

Abstract

In rat spinal cord slices, endothelin-1 and endothelin-3 enhanced [3H]inositol phosphate production between 1 nM and 10 microM (endothelin-1 > endothelin-3) while sarafotoxin 6c and the endothelin ETB receptor agonist IRL-1620 (Suc-[Glu9,Ala11,15]endothelin-1-(8-21)) were almost ineffective. BQ-123 (cyclo(D-Trp,D-Asp,L-Pro,D-Val,L-Leu), a selective… (More)

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Cite this paper

@article{Poulat1996ReceptorAM, title={Receptor and mechanism that mediate endothelin- and big endothelin-1-induced phosphoinositide hydrolysis in the rat spinal cord.}, author={Philippe Poulat and Jacques de Champlain and Pedro D'Orl{\'e}ans-Juste and Rex A Couture}, journal={European journal of pharmacology}, year={1996}, volume={315 3}, pages={327-34} }