Receptor activity-modifying protein 1 increases baroreflex sensitivity and attenuates Angiotensin-induced hypertension.

@article{Sabharwal2010ReceptorAP,
  title={Receptor activity-modifying protein 1 increases baroreflex sensitivity and attenuates Angiotensin-induced hypertension.},
  author={Rasna Sabharwal and Zhongming Zhang and Yongjun Lu and François M. Abboud and Andrew F Russo and Mark W. Chapleau},
  journal={Hypertension},
  year={2010},
  volume={55 3},
  pages={627-35}
}
Calcitonin gene-related peptide (CGRP) is a powerful vasodilator that interacts with the autonomic nervous system. A subunit of the CGRP receptor complex, receptor activity-modifying protein 1 (RAMP1), is required for trafficking of the receptor to the cell surface and high-affinity binding to CGRP. We hypothesized that upregulation of RAMP1 would favorably enhance autonomic regulation and attenuate hypertension. Blood pressure, heart rate, and locomotor activity were measured by radiotelemetry… CONTINUE READING
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