Receptor Specificity of the Fibroblast Growth Factor Family*

@article{Ornitz1996ReceptorSO,
  title={Receptor Specificity of the Fibroblast Growth Factor Family*},
  author={David M. Ornitz and Jingsong Xu and Jennifer S. Colvin and Donald G. McEwen and Craig A. MacArthur and François Coulier and Guang Gao and Mitchell Goldfarb},
  journal={The Journal of Biological Chemistry},
  year={1996},
  volume={271},
  pages={15292 - 15297}
}
Fibroblast growth factors (FGFs) are essential molecules for mammalian development. The nine known FGF ligands and the four signaling FGF receptors (and their alternatively spliced variants) are expressed in specific spatial and temporal patterns. The activity of this signaling pathway is regulated by ligand binding specificity, heparan sulfate proteoglycans, and the differential signaling capacity of individual FGF receptors. To determine potentially relevant ligand-receptor pairs we have… 

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References

SHOWING 1-10 OF 70 REFERENCES
Expression and Biological Activity of Mouse Fibroblast Growth Factor-9 (*)
TLDR
FGF-9 binds to and activates the “b” splice form of FGFR3, thus becoming the first FGF ligand besides FGF-1 to activate this highly specific member of the FGF receptor family.
Fibroblast growth factor receptor‐4 shows novel features in genomic structure, ligand binding and signal transduction.
TLDR
An FGF binding profile for FGFR‐4 is established with aFGF having the highest affinity, followed by K‐FGF/hst‐1 and bFGF, and FGF‐6 was found to bind to FGFR•4 in ligand competition experiments.
Fibroblast growth factor receptors have different signaling and mitogenic potentials.
TLDR
Compared the properties of BaF3 murine lymphoid cells and L6 rat myoblast cells engineered to express FGFR-1 orFGFR-4 are compared, finding that the signaling and biological responses elicited by different FGF receptors substantially differ.
Fibroblast growth factor receptor (FGFR) 3. Alternative splicing in immunoglobulin-like domain III creates a receptor highly specific for acidic FGF/FGF-1.
TLDR
It is demonstrated both by binding studies on genetically engineered soluble receptors and by the mitogenic response of growth factor-dependent cell lines that this splice variant of FGFR3 (FGFR3 IIIb), by binding only acidic FGF (aFGF/FGF-1), has the most restricted ligand binding properties of any FGFR thus far described.
Receptor Binding and Mitogenic Properties of Mouse Fibroblast Growth Factor 3
TLDR
A comparison of two mammary epithelial cell lines showed a marked difference of potency and dependence upon heparin in their response to mouse Fgf3, suggesting a complex interaction between the ligand and its low and high affinity receptors.
...
...