Receptor Specificity of the Fibroblast Growth Factor Family*

@article{Ornitz1996ReceptorSO,
  title={Receptor Specificity of the Fibroblast Growth Factor Family*},
  author={David M. Ornitz and Jingsong Xu and Jennifer S. Colvin and Donald G. McEwen and Craig A. MacArthur and François Coulier and Guang Gao and Mitchell Goldfarb},
  journal={The Journal of Biological Chemistry},
  year={1996},
  volume={271},
  pages={15292 - 15297}
}
Fibroblast growth factors (FGFs) are essential molecules for mammalian development. The nine known FGF ligands and the four signaling FGF receptors (and their alternatively spliced variants) are expressed in specific spatial and temporal patterns. The activity of this signaling pathway is regulated by ligand binding specificity, heparan sulfate proteoglycans, and the differential signaling capacity of individual FGF receptors. To determine potentially relevant ligand-receptor pairs we have… 
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Receptor Specificity of the Fibroblast Growth Factor Family
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This study completes the mitogenesis-based comparison of receptor specificity of the entire FGF family under standard conditions and should help in interpreting and predicting in vivo biological activity.
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Dimmerization of receptor monomers upon ligand binding is likely to be a requisite for activation of the kinase domains, leading to receptor trans phosphorylation, and the potential roles of these signal transduction molecules in FGF-induced biological responses and in pathological processes are discussed.
Fibroblast growth factors and their receptors in the central nervous system
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Fibroblast growth factors and their receptors constitute an elaborate signaling system that participates in many developmental and repair processes of virtually all mammalian tissues and are major determinants of neuronal survival both during development and during adulthood.
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FGF signaling also appears to play a role in tumor growth and angiogenesis, and autocrine FGF signaling may be particularly important in the progression of steroid hormone-dependent cancers to a hormone-independent state.
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Role of Heparan Sulfate in Fibroblast Growth Factor Signaling
Molecular characteristics of fibroblast growth factor-fibroblast growth factor receptor-heparin-like glycosaminoglycan complex.
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It is proposed that the FGF-FGFR interaction mediated by the 'conserved' primary site interactions is likely to be similar if not identical for the entire FGF family, whereas the 'variable' secondary sites, on both FGF as well as FGFR mediates specificity of a given FGF to a given FGFR isoform.
Isoforms of Receptors of Fibroblast Growth Factors
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  • Biology
    Journal of cellular physiology
  • 2014
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A better understanding of the diversity of FGF signaling in different developmental contexts and diseased states can be achieved through increased knowledge of the presence of specific FGFR isoforms and their impact on downstream signaling and functions.
Structural basis for fibroblast growth factor receptor activation.
Fibroblast growth factor receptors and their ligands in the adult rat kidney.
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The distributions of the FGFRs in the normal adult kidney and the restricted expression of FGF ligands suggest that specific FGFs have distinct and important roles in the maintenance of normal kidney structure and function.
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