Receptor Occupancy and Tissue Response

  title={Receptor Occupancy and Tissue Response},
  author={Mark Nickerson},
ONE of the cornerstones of all quantitative applications of classical receptor theory has been the postulate that the response of a given organ or tissue is proportional to the number of receptors occupied by the activating agent, and that the maximal response occurs when all receptors are occupied. Although never proved experimentally, and perhaps a priori somewhat unlikely in view of the complex nature of tissue responses, this relationship is necessary if agonist dose – response curves are… CONTINUE READING

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