Receptor-Mediated Gene Targeting to Tissues In Vivo Following Intravenous Administration of Pegylated Immunoliposomes

@article{Shi2001ReceptorMediatedGT,
  title={Receptor-Mediated Gene Targeting to Tissues In Vivo Following Intravenous Administration of Pegylated Immunoliposomes},
  author={Ningya Shi and Ruben J. Boado and William M Pardridge},
  journal={Pharmaceutical Research},
  year={2001},
  volume={18},
  pages={1091-1095}
}
Purpose. Gene therapy has been limited by the immunogenicity of viral vectors, by the inefficiency of cationic liposomes, and by the rapid degradation in vivofollowing the injection of naked DNA. The present work describes a new approach that enables the non-invasive, non-viral gene therapy of the brain and peripheral organs following an intravenous… CONTINUE READING