Receptor-Mediated Endocytosis and Brain Delivery of Therapeutic Biologics

  title={Receptor-Mediated Endocytosis and Brain Delivery of Therapeutic Biologics},
  author={Guangqing Xiao and Liang-Shang Gan},
  booktitle={International journal of cell biology},
Transport of macromolecules across the blood-brain-barrier (BBB) requires both specific and nonspecific interactions between macromolecules and proteins/receptors expressed on the luminal and/or the abluminal surfaces of the brain capillary endothelial cells. Endocytosis and transcytosis play important roles in the distribution of macromolecules. Due to the tight junction of BBB, brain delivery of traditional therapeutic proteins with large molecular weight is generally not possible. There are… CONTINUE READING