Receptor-Mediated Delivery of Astaxanthin-Loaded Nanoparticles to Neurons: An Enhanced Potential for Subarachnoid Hemorrhage Treatment

@article{You2019ReceptorMediatedDO,
  title={Receptor-Mediated Delivery of Astaxanthin-Loaded Nanoparticles to Neurons: An Enhanced Potential for Subarachnoid Hemorrhage Treatment},
  author={Z. You and Qi Wu and Xiao-ming Zhou and X. Zhang and Bin Yuan and Li-li Wen and Wei-dong Xu and Sheng Cui and Xiang-Long Tang and Xintong Zhang},
  journal={Frontiers in Neuroscience},
  year={2019},
  volume={13}
}
Astaxanthin (ATX) is a carotenoid that exerts strong anti-oxidant and anti-inflammatory property deriving from its highly unsaturated molecular structures. However, the low stability and solubility of ATX results in poor bioavailability, which markedly hampers its application as therapeutic agent in clinic advancement. This study investigated a promising way of transferrin conjugated to poly (ethylene glycol) (PEG)-encapsulated ATX nanoparticles (ATX-NPs) on targeted delivery and evaluated the… Expand
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