Reception of Slit requires only the chondroitin-sulphate-modified extracellular domain of Syndecan at the target cell surface.

@article{Chanana2009ReceptionOS,
  title={Reception of Slit requires only the chondroitin-sulphate-modified extracellular domain of Syndecan at the target cell surface.},
  author={Bhavna Chanana and Patrick Steigemann and Herbert Jaeckle and Gerd Vorbrueggen},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={2009},
  volume={106 29},
  pages={11984-8}
}
Syndecan (Sdc) is a conserved transmembrane heparan sulfate proteoglycan (HSPG) bearing additional chondroitin sulfate (CS) modifications on its extracellular domain. In vertebrates, this extracellular domain of Sdc is shed and acts as a soluble effector of cellular communication events, and its cytoplasmic domain participates in intracellular signaling needed to maintain epithelial integrity. In Drosophila, Sdc has been shown to be necessary for Slit signaling-dependent axon and myotube… CONTINUE READING