Recently identified colon cancer predispositions: MYH and MSH6 mutations.

@article{Kastrinos2007RecentlyIC,
  title={Recently identified colon cancer predispositions: MYH and MSH6 mutations.},
  author={Fay Kastrinos and Sapna Syngal},
  journal={Seminars in oncology},
  year={2007},
  volume={34 5},
  pages={418-24}
}
Single-gene germline mutations conferring a high lifetime risk of colorectal cancer (CRC) account for up to 6% of all CRC cases. The most widely studied monogenic colorectal cancer syndromes include familial adenomatous polyposis (FAP) and Lynch syndrome. However, additional syndromes continue to be defined and new predisposition genes are continuing to be identified. Most recently, MYH-associated polyposis (MAP) and an "atypical Lynch syndrome" related to the presence of MSH6 mutations have… CONTINUE READING

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