Recently discovered T cell subsets cannot keep their commitments.

  title={Recently discovered T cell subsets cannot keep their commitments.},
  author={Terry B. Strom and Maria Koulmanda},
  journal={Journal of the American Society of Nephrology : JASN},
  volume={20 8},
After activation by antigen/MHC (signal 1) and CD28-dependent co-stimulation (signal 2), resting CD4(+) T cells commit to one of a variety of functionally and molecularly defined phenotypes. Two long established CD4 phenotypes, Th1 and Th2 cells, have been regarded as terminally differentiated formats. Recently, two additional phenotypes, tissue-protective… CONTINUE READING

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