Recent uses of topological indices in the development of in silico ADMET models.

@article{Votano2005RecentUO,
  title={Recent uses of topological indices in the development of in silico ADMET models.},
  author={Joseph R. Votano},
  journal={Current opinion in drug discovery & development},
  year={2005},
  volume={8 1},
  pages={32-7}
}
  • Joseph R. Votano
  • Published 2005 in Current opinion in drug discovery & development
Topological indices are employed in an ever-widening family of quantitative models to describe the structural attributes of compounds as these relate to experimental endpoints in a host of physicochemical and biological processes. This is especially true where attention to ADMET (absorption, distribution, metabolism, excretion and toxicity) properties is a priority, using various training or learning algorithms to construct quantitative structure-activity or -property relationship ADMET models… CONTINUE READING

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