Recent trends in platelet antigen/antibody detection


The detection of platelet antigens and platelet antibodies has always been difficult. Recent technical achievements are due to the availability of more specific and sensitive reagents (i.e. F(ab)2 fragments; higher specific activity of labels; monoclonal antibodies directed against platelet membrane constituents etc.) and the application of advanced immunological assays to platelet immunology (i.e. blotting assays, “capture”-ELISA's and radioimmunoprecipitation in conjunction with SDS polyacrylamide gel electrophoresis). These techniques have permitted the definition and immunochemical characterization of new platelet allo- and autoantigens, have assisted in clinical diagnosis and promoted our understanding of pathogenic mechanisms. Illustrative examples are presented and discussed.

DOI: 10.1007/BF00320246

10 Figures and Tables


Citations per Year

441 Citations

Semantic Scholar estimates that this publication has 441 citations based on the available data.

See our FAQ for additional information.

Cite this paper

@article{MuellerEckhardt1989RecentTI, title={Recent trends in platelet antigen/antibody detection}, author={C. Mueller-Eckhardt and Volker Kiefel and Sentot Santoso}, journal={Blut}, year={1989}, volume={59}, pages={35-43} }