Recent structural insights into the expanding world of carbohydrate-active enzymes.

@article{Davies2005RecentSI,
  title={Recent structural insights into the expanding world of carbohydrate-active enzymes.},
  author={Gideon J Davies and Tracey M Gloster and Bernard Henrissat},
  journal={Current opinion in structural biology},
  year={2005},
  volume={15 6},
  pages={637-45}
}
Enzymes that catalyse the synthesis and breakdown of glycosidic bonds account for 1-3% of the proteins encoded by the genomes of most organisms. At the current rate, over 12 000 glycosyltransferase and glycoside hydrolase open reading frames will appear during 2006. Recent advances in the study of the structure and mechanism of these carbohydrate-active enzymes reveal that glycoside hydrolases continue to display a wide variety of scaffolds, whereas nucleotide-sugar-dependent… CONTINUE READING