Recent status in the occurrence of leukemia in growth hormone-treated patients in Japan. GH Treatment Study Committee of the Foundation for Growth Science, Japan.

@article{Nishi1999RecentSI,
  title={Recent status in the occurrence of leukemia in growth hormone-treated patients in Japan. GH Treatment Study Committee of the Foundation for Growth Science, Japan.},
  author={Yoshikazu Nishi and Toshiaki Tanaka and Kazue Takano and Kenji Fujieda and Yutaka Igarashi and Kunihiko Hanew and Takeki Hirano and Susumu Yokoya and Katsuhiko Tachibana and Tomoyuki Saito and Shinichiro Watanabe},
  journal={The Journal of clinical endocrinology and metabolism},
  year={1999},
  volume={84 6},
  pages={1961-5}
}
The Foundation for Growth Science in Japan has monitored the safety and efficacy of GH treatment in GH-deficient patients since 1975. Data were collected from more than 32,000 patients up to December 31, 1997. New leukemia was observed in 14 patients and myelodysplastic syndrome (MDS) in one patient. The types of leukemia were acute lymphocytic leukemia (n = 6; 40%), acute myelocytic leukemia or MDS (n = 7; 47%), and chronic myelocytic leukemia (n = 2; 13%). Leukemia developed in 9 patients… CONTINUE READING

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