Recent progress in the study of G protein-coupled receptors with molecular dynamics computer simulations.

@article{Grossfield2011RecentPI,
  title={Recent progress in the study of G protein-coupled receptors with molecular dynamics computer simulations.},
  author={Alan Grossfield},
  journal={Biochimica et biophysica acta},
  year={2011},
  volume={1808 7},
  pages={1868-78}
}
G protein-coupled receptors (GPCRs) are a large, biomedically important family of proteins, and the recent explosion of new high-resolution structural information about them has provided an enormous opportunity for computational modeling to make major contributions. In particular, molecular dynamics simulations have become a driving factor in many areas of GPCR biophysics, improving our understanding of lipid-protein interaction, activation mechanisms, and internal hydration. Given that… CONTINUE READING

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  • K. Gawrisch
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