Recent progress in the medicinal chemistry of 2,4-diaminopyrimidines.

@article{Roth1982RecentPI,
  title={Recent progress in the medicinal chemistry of 2,4-diaminopyrimidines.},
  author={Barbara Roth and C. C. Cheng},
  journal={Progress in medicinal chemistry},
  year={1982},
  volume={19},
  pages={
          269-331
        }
}
  • B. Roth, C. Cheng
  • Published 1982
  • Biology, Chemistry
  • Progress in medicinal chemistry

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  • Chemistry
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  • 1989

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  • Chemistry, Biology
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  • 1994

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TLDR
An excellent review of DHFR inhibition and their relevance to antimicrobial and parasitic chemotherapy was presented and advances in design, synthesis, and biological evaluations in structural modifications of TMP as DHFR inhibitors are highlighted.

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Abstract Substituted quinolines containing a 1,2,4-triazole moiety were synthesized using reported methods. The molecular docking studies support the experimental results that these compounds are

Thymidylate synthase inhibitors.

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TLDR
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Synthesis, antimicrobial activity and molecular modeling study of substituted 5-aryl-pyrimido[5,4-c]quinoline-2,4-diones

TLDR
Results of the antimicrobial screening showed that compounds 5d, 5e, 5f, 5h and 5k have broad-spectrum antibacterial efficacy being moderately active against all the tested Gram +ve and two Gram −ve bacteria.

Synthesis and antibacterial evaluation of new azo-pyrimidine derivatives

  • M. Abdelgawad
  • Chemistry, Biology
    Journal of Applied Pharmaceutical Science
  • 2019
TLDR
Two new synthesized azo-compounds showed weak (III b) to strong (IV b) antibacterial activity and the molecular operating environment docking program was used for the prediction of the compound IV b action mechanism.
...

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