Recent progress in the medicinal chemistry of 2,4-diaminopyrimidines.

@article{Roth1982RecentPI,
  title={Recent progress in the medicinal chemistry of 2,4-diaminopyrimidines.},
  author={B. Roth and C. C. Cheng},
  journal={Progress in medicinal chemistry},
  year={1982},
  volume={19},
  pages={
          269-331
        }
}
  • B. Roth, C. C. Cheng
  • Published 1982
  • Biology, Medicine
  • Progress in medicinal chemistry
  • Publisher Summary This chapter discusses the developments in the study of 2,4-diaminopyrimidines since 1970 and analogues as targets for the chemotherapy of infectious disease. This category of compounds owes its activity to inhibition of the enzyme dihydrofolate reductase that is vital to life processes and that differs markedly from species to species. The chapter discusses the enzyme itself and its mode of binding to inhibitors. In addition to simple pyrimidines, bicyclic analogues such as… CONTINUE READING
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