Recent progress in the identification and development of InhA direct inhibitors of Mycobacterium tuberculosis.

@article{Lu2010RecentPI,
  title={Recent progress in the identification and development of InhA direct inhibitors of Mycobacterium tuberculosis.},
  author={X Y Lu and Qidong You and Yu Dao Chen},
  journal={Mini reviews in medicinal chemistry},
  year={2010},
  volume={10 3},
  pages={181-92}
}
The InhA-related enoyl-ACP reductase, an enzyme involved in fatty acid synthesis, is one of the best validated targets for the development of anti-tubercular agents. However, the majority of isoniazid (INH)-resistant clinical strains are observed mainly due to the emergence of KatG mutants that do not form an INH-NAD adduct. Thus compounds that directly inhibit InhA avoiding activation by KatG would be promising candidates for combating MDR-TB. Herein, some predominant examples of InhA direct… CONTINUE READING

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