Recent progress in gene-directed enzyme prodrug therapy: an emerging cancer treatment.

  • G. W. Both
  • Published 2009 in Current opinion in molecular therapeutics


The principle of gene-directed enzyme prodrug therapy (GDEPT) has existed for many years but, while simple in concept, the effective practical application of this therapy has proven to be challenging. Improvements in the efficacy of GDEPT have been achieved principally through the choice and development of more effective vectors, by optimizing and… (More)


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